Crossref Medline Google Scholar; 51. Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy. Implantable cardioverter defibrillators. Previous data have shown that various nonischemic cardiac diseases account for about 20% of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD. Dickinson MG, Ip JH, Olshansky B, et al. 1 A number of studies have shown syncope is an indicator of poor prognosis in this patient population. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Ont Health Technol Assess Ser. Current recommendations for ICD implantation are continually debated, justifying comprehensive individualized risk assessment. Crossref Medline Google Scholar; 51. © 2019 Elsevier Inc. All rights reserved. Some recent data, however, suggest that ICDs may not increase longevity in this population. Current guidelines recommend the use of implantable cardioverter-defibrillators (ICDs) for primary prevention of sudden cardiac death (SCD) in patients with nonischemic dilated cardiomyopathy (NIDCM), symptomatic heart failure, and left ventricular ejection fraction (LVEF) ≤ 35%. doi: 10.1111/1755-5922.12253. Identifying patients who are at highest risk for SCD is an ongoing challenge. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Nonischemic Dilated Cardiomyopathy. Sudden cardiac death in nonischemic cardiomyopathy: Refining risk assessment. Abstract Background: Current risk stratification for sudden cardiac death (SCD) in nonischemic dilated cardiomyopathy (NIDC) relies on left ventricular (LV) dysfunction, a poor marker of … Among NYHA functional class II/III nonischemic cardiomyopathy patients, an abnormal TWA test is associated with a 4-fold higher risk of cardiac death and life-threatening arrhythmias. An irregular heart beat and fainting may occur. Gulati and coauthors report on the association of myocardial fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. In this article, we review the definition, impact and underlying aetiology of SCD. USA.gov. Certain genetic mutations are linked to the condition. Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. Dickinson MG, Ip JH, Olshansky B, et al. NCI CPTC Antibody Characterization Program. Sudden cardiac death (SCD) is a major cause of mortality in patients with nonischemic cardiomyopathy (NICM). Heart Rhythm. Cardiovasc Ther. CONCLUSIONS: Techniques incorporating functional parameters, depolarization abnormalities, repolarization abnormalities, and arrhythmic markers provide only modest risk stratification for sudden cardiac death in patients with nonischemic dilated cardiomyopathy. Conversely, community-based studies have demonstrated that many at-risk individuals who may benefit from ICD therapy remain unprotected.  |  NLM Crossref … LVH = left ventricular hypertrophy; PVC = premature ventricular contraction. As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure. JAMA. NIH Prophylactic use: an evidence-based analysis. 2018 Aug 14;39(31):2859-2866. doi: 10.1093/eurheartj/ehy344. Implantable cardioverter-defibrillator; Nonischemic cardiomyopathy; Risk stratification; Sudden cardiac death. 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